Detailed view for TVAG_407890

Basic information

TDR Targets ID: 918089
Trichomonas vaginalis, dynein light intermediate chain, putative
Source Database / ID: 

pI: 4.9517 | Length (AA): 286 | MW (Da): 31598 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131077)

Species Accession Gene Product
Brugia malayi Bm1_12090   hypothetical protein
Brugia malayi Bm1_22100   dynein 2 light intermediate chain
Caenorhabditis elegans CELE_F02D8.3   Protein XBX-1
Drosophila melanogaster Dmel_CG3769   CG3769 gene product from transcript CG3769-RA
Echinococcus granulosus EgrG_000475500   Dynein intermediate chain
Echinococcus granulosus EgrG_000475600   Dynein intermediate chain
Echinococcus multilocularis EmuJ_000475600   Dynein intermediate chain
Echinococcus multilocularis EmuJ_000475500   Dynein intermediate chain
Homo sapiens ENSG00000138036   dynein, cytoplasmic 2, light intermediate chain 1
Leishmania braziliensis LbrM.32.3520   dynein light intermediate chain, putative
Leishmania donovani LdBPK_323430.1   dynein light intermediate chain, putative
Leishmania infantum LinJ.32.3430   dynein light intermediate chain, putative
Leishmania major LmjF.32.3230   dynein light intermediate chain, putative
Leishmania mexicana LmxM.31.3230   dynein light intermediate chain, putative
Loa Loa (eye worm) LOAG_12144   hypothetical protein
Mus musculus ENSMUSG00000024253   dynein cytoplasmic 2 light intermediate chain 1
Onchocerca volvulus OVOC7345   Cytoplasmic dynein 2 light intermediate chain 1 homolog
Onchocerca volvulus OVOC7272   Cytoplasmic dynein 2 light intermediate chain 1 homolog
Schistosoma japonicum Sjp_0207550   ko:K10417 dynein light intermediate chain 2, cytosolic, putative
Schistosoma mansoni Smp_159340   hypothetical protein
Schmidtea mediterranea mk4.001573.06   Cytoplasmic dynein 2 light intermediate chain 1
Trypanosoma brucei gambiense Tbg972.11.18970   dynein light intermediate chain, putative
Trypanosoma brucei Tb927.11.16810   dynein light intermediate chain D1bLIC, putative
Trypanosoma cruzi TcCLB.511025.10   dynein light intermediate chain, putative
Trypanosoma cruzi TcCLB.511533.19   dynein light intermediate chain, putative
Trypanosoma cruzi TcCLB.503927.9   dynein light intermediate chain, putative
Trichomonas vaginalis TVAG_407890   dynein light intermediate chain, putative
Trichomonas vaginalis TVAG_277480   conserved hypothetical protein

Essentiality

TVAG_407890 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.8570 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.8570 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.8570 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.8570 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_407890 (Trichomonas vaginalis), dynein light intermediate chain, putative
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